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A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses
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USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis
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Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
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The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer
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CELL CYCLE (2012)
Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme
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Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications
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EMBO MOLECULAR MEDICINE (2012)
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Met Kinase-dependent Loss of the E3 Ligase Cbl in Gastric Cancer
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells
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Receptor Tyrosine Kinases and Targeted Cancer Therapeutics
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Hallmarks of Cancer: The Next Generation
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Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
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CHEMISTRY & BIOLOGY (2011)
Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives
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CURRENT CANCER DRUG TARGETS (2011)
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
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EMBO JOURNAL (2011)
JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress
Juhong Liu et al.
EMBO JOURNAL (2011)
USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1
Xinna Zhang et al.
EMBO JOURNAL (2011)
Usp18 Regulates Epidermal Growth Factor (EGF) Receptor Expression and Cancer Cell Survival via MicroRNA-7
Jason E. Duex et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
Roya Babaei-Jadidi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/β-Catenin Signaling
Tony T. H. Lui et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
Padraig D'Arcy et al.
NATURE MEDICINE (2011)
Inhibition of Chromatin Remodeling by Polycomb Group Protein Posterior Sex Combs Is Mechanistically Distinct from Nucleosome Binding
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BIOCHEMISTRY (2010)
The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression
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CANCER RESEARCH (2010)
Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis
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CANCER RESEARCH (2010)
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
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CELL (2010)
A screen for deubiquitinating enzymes involved in the G2/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability
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Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
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p53-Altered FBXW7 Expression Determines Poor Prognosis in Gastric Cancer Cases
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
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The Proteasome-Associated Deubiquitinating Enzyme Usp14 Is Essential for the Maintenance of Synaptic Ubiquitin Levels and the Development of Neuromuscular Junctions
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USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A
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Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS
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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
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