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Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury

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Summary: A biomarker is a measurable characteristic indicating normal biologic processes, pathogenic processes, or responses to treatment. Reviewing seven biomarker categories revealed minimal overlap in biomarker candidates between TBI, epilepsy, and PTE.

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Summary: This study investigated the antiepileptogenic potential of levetiracetam in traumatic brain injury models in rats. Results showed that early administration of levetiracetam significantly reduced the proportion of slices exhibiting stimulus-evoked epileptiform activity and increased the stimulus intensity required to trigger epileptiform bursts in injured slices.

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Summary: The mechanisms by which brain injuries lead to epilepsy are not fully understood, and effective preventive measures are lacking. Animal studies have shown that drugs like anticholinergic agents may modify the course of post-traumatic epilepsy, with promising results seen in scopolamine and biperiden. Biperiden has been shown to decrease seizure incidence and intensity, making it a potential candidate for further investigation as an antiepileptogenic agent. Safety assessments in TBI patients have confirmed the safety of biperiden, and now a double-blind, randomized, placebo-controlled trial is underway to evaluate its efficacy in preventing epilepsy development.

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