Selective synthesis of fluorinated biaryls by [MCl2(PhPEWO-F)] (M = Ni, Pd) catalysed Negishi cross-coupling

Highly selective cross-couplings to polyfluorinated assymmetric biaryls, including the symmetric biaryl C6F5-C6F5, are achieved at relatively low temperature (80 degrees C) and in short times using [MCl2(PhPEWO-F)] catalysts (M = Ni, Pd; PhPEWO-F = 1-(PPh2), 2-(CH=CH-C(O)Ph)-C6F4), (ArI)-I-F, and Zn(C6F5)(2) as example of highly fluorinated nucleophile.

Automated summary

Highly selective cross-coupling reactions to polyfluorinated assymmetric biaryls, including the symmetric biaryl C6F5-C6F5, were achieved at relatively low temperature (80 degrees C) and in short times using [MCl2(PhPEWO-F)] catalysts (M = Ni, Pd), with (ArI)-I-F and Zn(C6F5)(2) as examples of highly fluorinated nucleophiles.