Pd-Catalyzed allylic C-H activation to seven-membered N,O-heterocycles

Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered N,O-heterocycles such as 1,4-benzoxazepines (1,4-BZOs), 1,4-benzodiazepinones (1,4-BZDs) and 1,4-oxazepanes in good to excellent yields. Straightforward derivatization of the olefinated 1,4-BZO shows the synthetic utility of this methodology.

Automated summary

The Pd-catalyzed allylic C-H activation of simple olefins allows for the easy synthesis of seven-membered N,O-heterocycles such as 1,4-BZOs, 1,4-BZDs, and 1,4-oxazepanes in good to excellent yields. The straightforward derivatization of the olefinated 1,4-BZO demonstrates the synthetic utility of this methodology.