Non-Hodgkin lymphoma of bone of the femur and humerus: a case report and review of the literature

Lymphoma of bone is a rare neoplasm composed of malignant lymphoid cells, producing a tumefactive lesion within bone. We report a 13-year-old male who presented with progressively increasing swellings at the right shoulder and right mid-thigh for one month. Radiological images revealed lytic destructive lesions associated with soft tissue masses in both sites and a pathological fracture on the right humerus. The patient had no significant medical history. Histological, immunohistochemical and fluorescent in-situ hybridization assessment of biopsies from the lesions confirmed the diagnosis of primary non-Hodgkin lymphoma of bone. Unfortunately, due to coronavirus disease 2019 outbreak, the patient was unable to follow-up treatment and died shortly after establishment of the diagnosis. Delay in diagnosis and treatment is of serious concern when it comes to improve the prognosis of patients with this disease.

Automated summary

Primary non-Hodgkin lymphoma of bone is a rare neoplasm composed of malignant lymphoid cells, and delay in diagnosis and treatment can significantly impact patient prognosis. A case study reported a 13-year-old male with this condition, who unfortunately passed away shortly after diagnosis due to the COVID-19 outbreak, highlighting the importance of timely follow-up and treatment for patients with this disease.