期刊
THERANOSTICS
卷 11, 期 18, 页码 8909-8925出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.61651
关键词
Chemodynamic therapy; Nanotheranostics; Microenvironment-responsive; Magnetic resonance imaging; Synergistic therapy
资金
- National Natural Science Foundation of China [81871403]
- Key Research and Development Program of Zhejiang Province [2019C03014]
- China Postdoctoral Science Foundation [2020M671716]
- Fundamental Research Funds for the Central Universities
This study presents a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging. The nanosystem improves the cycling time and solubility of chemotherapeutic drugs, releasing them gradually in tumor tissues through glutathione-triggered biodegradation. With improved generation of reactive oxygen species and controlled release of the chemotherapeutic drug, it shows excellent inhibition of tumor growth in colorectal cancer models.
Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging (MRI). Methods: The biodegradable nanosystem is synthesized using a surface-modified chain transfer agent for surface-initiated living radical polymerization of the chemotherapeutic drug. Results: In this nanosystem, named CAMNSN@PSN38, the cycling time and solubility of the chemotherapeutic drug are improved. The nanoparticles delivered to tumor tissues gradually release the chemotherapeutic drug and Mn2+ through glutathione (GSH)-triggered biodegradation in the tumor microenvironment. SN38, the released chemotherapeutic drug, not only shows excellent chemical therapy effects but also improves the generation of H2O2. Furthermore, with the Fenton-like agent Mn2+, the generation of reactive oxygen species (ROS) is improved markedly. Finally, CAMNSN@PSN38 shows excellent inhibition of tumor growth in three colorectal cancer tumor models, with an improved accumulation of ROS and controlled release of SN38. Conclusions: The CAMNSN@PSN38-mediated chemodynamic/chemical synergistic therapy provides a promising paradigm for the treatment and MRI-guided therapy of colorectal cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据