Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives

A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazole has been established with alpha-carbonyl alkyl bromide. This protocol provides an efficient and practical method for the synthesis of various alpha-carbonyl alkyl-substituted benzimidazo[2,1-alpha]isoquinolin-6(5H)-ones in outstanding yields, mild reaction conditions and excellent functional group tolerance.

Automated summary

A visible-light-driven cascade radical cyclization process has been established for the synthesis of alpha-carbonyl alkyl-substituted benzimidazo[2,1-alpha]isoquinolin-6(5H)-ones. This protocol offers an efficient and practical method with outstanding yields, mild reaction conditions, and excellent functional group tolerance.