期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 41, 页码 8999-9003出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob01697k
关键词
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资金
- National Natural Science Foundation of China [21871283]
- project of Science and Technology Commission of Shanghai Municipality in China [21010503800]
- Shanghai Engineering Research Center of Green Fluoro Pharmaceutical Technology
- Science Research Foundation of Shanghai Institute of Technology
This paper describes a novel copper-catalyzed synthesis of arenesulfonyl fluorides, using arylhydrazine hydrochlorides as safe precursors of aryl radicals, along with DABSO and NFSI as sulfonyl and fluorine sources, under mild conditions to achieve high yields.
This paper reports a convenient copper-catalyzed three-component conversion of arylhydrazine hydrochlorides to arenesulfonyl fluorides in good yields under mild conditions, using 1,4-diazabicyclo [2.2.2]octane bis(sulfur dioxide) (DABSO) as a sulfonyl source and N-fluorobenzenesulfonimide (NFSI) as a fluorine source based on a radical sulfur dioxide insertion and fluorination strategy. Notably, arylhydrazine hydrochloride is used as a safe precursor of aryl radicals.
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