期刊
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12968-021-00800-w
关键词
Mitral valve prolapse; Cardiovascular magnetic resonance; Mitral regurgitation; Myocardial strain
资金
- Sociedad Espanola de Cardiologia, Madrid, Spain
- Ministerio de Ciencia, Innovacion y Universidades
- Pro CNIC Foundation
- Severo Ochoa Center of Excellence [SEV-2015-0505]
The study revealed that even in the absence of significant mitral regurgitation, patients with mitral valve prolapse exhibit abnormalities in the left ventricle, including LV enlargement and basal inferolateral hypertrophy. These abnormalities persist even without significant MR, suggesting that MVP not only affects the mitral valve but also involves the adjacent myocardium.
Introduction Mitral valve (MV) prolapse (MVP) is a primary valvular abnormality. We hypothesized that additionally there are concomitant abnormalities of the left ventricle (LV) and MV apparatus in this entity even in the absence of significant mitral regurgitation (MR). Objective To characterize MV and LV anatomic and functional features in MVP with preserved LV ejection fraction, with and without significant MR, using cardiovascular magnetic resonance (CMR). Methods Consecutive MVP patients (n = 80, mean 52 years, 37% males) with preserved LV ejection fraction, and 44 controls (46 years, 52% males) by CMR were included, as well as 13 additional patients with borderline MVP. From cine images we quantified LV volumes, MV and LV anatomic measurements (including angle between diastolic and systolic annular planes, annular displacement, and basal inferolateral hypertrophy) and, using feature tracking, longitudinal and circumferential peak systolic strains. Results Significant MR was found in 46 (56%) MVP patients. Compared with controls, MVP patients had LV enlargement, basal inferolateral hypertrophy, higher posterior annular excursion, and reduced shortening of the papillary muscles. LV basal strains were significantly increased, particularly in several basal segments. These differences remained significant in patients without significant MR, and many persisted in borderline MVP. Conclusions In patients with MVP and preserved LV ejection fraction there is LV dilatation, basal inferolateral hypertrophy, exaggerated posterior annular displacement and increased basal deformation, even in the absence of significant MR or overt MVP. These findings suggest that MVP is a disease not only of the MV but also of the adjacent myocardium.
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