期刊
CELL REPORTS MEDICINE
卷 2, 期 9, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.xcrm.2021.100405
关键词
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资金
- Operation Warp Speed
- SA-MANA Kay MGH research scholars award
- Ragon Institute of MGH, MIT and Harvard
- Massachusetts Consortium on Pathogen Readiness (MassCPR)
- NIH [3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-02S1, 1U01CA260476-01, CIVIC75N93019C00052]
- National Science Foundation graduate research fellowship [1745302]
- Gates Foundation Global Health Vaccine Accelerator Platform funding [OPP1146996, INV-001650]
- COVID-19 Therapeutics Accelerator [INV-006133]
- Musk Foundation
- Centers of Excellence for Influenza Research and Surveillance (CEIRS) [HHSN272201400008C]
- JPB Foundation
- Open Philanthropy Project [2020-215611 [5384]]
- Bill and Melinda Gates Foundation [INV-006133, INV-001650] Funding Source: Bill and Melinda Gates Foundation
Newly approved vaccines have shown significant efficacy in limiting disease associated with SARS-CoV-2, single doses may prevent disease through combined Fc/Fab functions, but two doses may be crucial to prevent further transmission of the virus and emerging variants.
Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a spectrum of antibody titers is urgently required. Thus, we profiled the humoral immune response in a cohort of non-human primates immunized with a recombinant SARS-CoV-2 spike glycoprotein (NVX-CoV2373) at two doses, administered as a single-or two-dose regimen. Both antigen dose and boosting significantly altered neutralization titers and Fc-effector profiles, driving unique vaccine-induced antibody fingerprints. Combined differences in antibody effector functions and neutralization were associated with distinct levels of protection in the upper and lower respiratory tract. Moreover, NVX-CoV2373 elicited antibodies that functionally targeted emerging SARS-CoV-2 variants. Collectively, the data presented here suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
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