N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains

Article Biochemistry & Molecular Biology

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Piyada Supasa et al.

Summary: Research on the UK-dominant variant B.1.1.7 shows that it is harder to neutralize than the parental virus, but widespread escape from antibodies or monoclonal antibodies has not been observed yet.

CELL (2021)

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Article Microbiology

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Gabriele Cerutti et al.

Summary: Structural analysis revealed that seven potent NTD-directed neutralizing antibodies target a common surface on NTD, forming a single supersite different from the recognition pattern of RBD-directed antibodies.

CELL HOST & MICROBE (2021)

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Article Multidisciplinary Sciences

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang et al.

Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.

NATURE (2021)

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Article Multidisciplinary Sciences

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

Kevin R. McCarthy et al.

Summary: The translation above discusses zoonotic pandemics caused by animal viruses spilling over into highly susceptible human populations, specifically focusing on the evolution of coronaviruses in human hosts and the impact of recurrent deletions in the spike glycoprotein on antibody epitopes. These studies help understand the antigenic evolution and adaptive evolution of SARS-CoV-2.

SCIENCE (2021)

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Article Biochemistry & Molecular Biology

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

Matthew McCallum et al.

Summary: The study identifies 41 human monoclonal antibodies that recognize the N-terminal domain of the SARS-CoV-2 spike protein and exhibit strong neutralizing activity. These antibodies inhibit cell-to-cell fusion, activate effector functions, and protect animals from virus challenge, highlighting the importance of NTD-specific neutralizing antibodies for protective immunity and vaccine development. Several SARS-CoV-2 variants with mutations in the NTD supersite suggest ongoing selective pressure on the virus.

CELL (2021)

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Article Immunology

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant

Carl Graham et al.

Summary: The interaction between the SARS-CoV-2 Spike receptor binding domain (RBD) and the host cell receptor ACE2 is crucial for viral entry, with RBD being the main target for neutralizing antibodies. Mutations in RBD, N-terminal domain (NTD), and S2 subunits of Spike have been found in circulating SARS-CoV-2 variants. This study isolates and characterizes monoclonal antibodies targeting different epitopes on RBD, NTD, and S2 to understand how these mutations affect antigenicity and neutralization resistance.

IMMUNITY (2021)

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Article Multidisciplinary Sciences

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

William N. Voss et al.

Summary: The study found that in convalescent individuals from COVID-19, the IgG antibodies primarily target epitopes outside the receptor binding domain (RBD) in the spike glycoprotein. It also revealed a protective NTD antibody and an NTD epitope that is recurrently mutated in emerging SARS-CoV-2 variants.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern

Matthew McCallum et al.

Summary: The novel CAL.20C (B.1.427/B.1.429) variant carries spike protein mutations, resulting in reduced neutralizing titers in vaccinated individuals and convalescent individuals. The L452R mutation reduces neutralizing activity in RBD-specific monoclonal antibodies, while the S13I and W152C mutations lead to the total loss of neutralization in NTD-specific antibodies due to antigenic supersite remodeling.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

Yongfei Cai et al.

Summary: The study found that the B.1.1.7 variant has increased receptor binding affinity, while the B.1.351 variant has developed resistance to some neutralizing antibodies by reshaping antigenic surfaces on the spike protein.

SCIENCE (2021)

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Article Medicine, General & Internal

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Roujian Lu et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 productively infects human gut enterocytes

Mart M. Lamers et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Site-specific glycan analysis of the SARS-CoV-2 spike

Yasunori Watanabe et al.

SCIENCE (2020)

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Article Medicine, General & Internal

Multiorgan and Renal Tropism of SARS-CoV-2

Victor G. Puelles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Infectious Diseases

COVID-19, SARS and MERS: are they closely related?

N. Petrosillo et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Article Public, Environmental & Occupational Health

Variant analysis of SARS-CoV-2 genomes

Takahiko Koyama et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2020)

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Article Biochemistry & Molecular Biology

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

Christopher O. Barnes et al.

CELL (2020)

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Review Biochemistry & Molecular Biology

The molecular virology of coronaviruses

Ella Hartenian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Infectious Diseases

Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics

Eskild Petersen et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Biochemistry & Molecular Biology

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

Luca Piccoli et al.

CELL (2020)

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Article Multidisciplinary Sciences

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

Lihong Liu et al.

NATURE (2020)

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Article Multidisciplinary Sciences

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Xiangyang Chi et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Distinct conformational states of SARS-CoV-2 spike protein

Yongfei Cai et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Philip J. M. Brouwer et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Christopher O. Barnes et al.

NATURE (2020)

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Article Genetics & Heredity

Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource

Stephanie Portelli et al.

NATURE GENETICS (2020)

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Article Virology

The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoV

Mayanka Awasthi et al.

VIRUSES-BASEL (2020)

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Article Biochemistry & Molecular Biology

Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer

Victoria A. Avanzato et al.

CELL (2020)

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Review Biochemistry & Molecular Biology

Exploitation of glycosylation in enveloped virus pathobiology

Yasunori Watanabe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

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Article Biochemistry & Molecular Biology

Clustal Omega for making accurate alignments of many protein sequences

Fabian Sievers et al.

PROTEIN SCIENCE (2018)

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Article Biochemistry & Molecular Biology

Why are RNA virus mutation rates so damn high?

Siobain Duffy

PLOS BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

Harry C. Jubb et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

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Article Multidisciplinary Sciences

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Yuan Yuan et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Lorenzo Subissi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Virology

RNA replication errors and the evolution of virus pathogenicity and virulence

Isabel S. Novella et al.

CURRENT OPINION IN VIROLOGY (2014)

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Review Microbiology

The role of mutational robustness in RNA virus evolution

Adam S. Lauring et al.

NATURE REVIEWS MICROBIOLOGY (2013)

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Review Microbiology

Viral Quasispecies Evolution

Esteban Domingo et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2012)

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Article Medicine, General & Internal

Human monoclonal antibody combination against SARS coronavirus: Synergy and coverage of escape mutants

Jan ter Meulen et al.

PLOS MEDICINE (2006)

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Review Virology

Nidovirales:: Evolving the largest RNA virus genome

AE Gorbalenya et al.

VIRUS RESEARCH (2006)

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Article Immunology

Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies

YX He et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Oncology

Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases

K To et al.

JOURNAL OF PATHOLOGY (2004)

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Letter Virology

Severe acute respiratory syndrome coronavirus sequence characteristics and evolutionary rate estimate from maximum likelihood analysis

M Salemi et al.

JOURNAL OF VIROLOGY (2004)

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Article Biology

Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic

RM Anderson et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2004)

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Article Multidisciplinary Sciences

Electrostatics of nanosystems: Application to microtubules and the ribosome

NA Baker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains

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