期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 47, 期 3, 页码 221-230出版社
WILEY
DOI: 10.1111/eci.12725
关键词
Body iron stores; nested case-control; obesity; PREDIMED; soluble transferrin receptor; type 2 diabetes mellitus
资金
- Spanish Ministry of Health (Instituto de Salud Carlos III) [PI1001407, FIS PI10/0082, G03/140, RD06/0045]
- FEDER (Fondo Europeo de Desarrollo Regional)
- Public Health Division of the Department of Health of the Autonomous Government of Catalonia and Caixa Tarragona [10-1343]
Background Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects. Design A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3.9-6.5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (). Cases and controls were matched for age (67 vs. > 67 years), gender, dietary intervention group and BMI (27 vs. > 27 kg/m(2)). Results Waist circumference is the main determinant of sTfR concentrations in the whole sample (beta = 0.476, P < 0.001), in the obese (beta = 0.802, P < 0.001) and the nonobese (beta = 0.455, P = 0.003). Furthermore, sTfR is directly associated with the risk of T2DM in obese individuals (OR = 2.79; 95% CI: 1.35-5.77, P = 0.005) and inversely associated in nonobese individuals (OR = 0.40; 95% CI: 0.20-0.79, P = 0.015). Conclusions The association between sTfR levels and risk of T2DM in a population at high cardiovascular risk depend on the presence or absence of obesity. While in nonobese subjects elevated sTfR levels are associated with a decreased risk of developing T2DM, in obese subjects the risk increases. This suggests that obesity alters the relationship between sTfR and T2DM incidence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据