期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 47, 期 8, 页码 591-599出版社
WILEY
DOI: 10.1111/eci.12780
关键词
HIV; inflammation; intima-media thickness; microbial translocation; subclinical atherosclerosis
资金
- Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL-Fundacion FISABIO)
- Gilead Sciences (Fellowship Program)
Background Pathogenesis of atherosclerosis is complex, and differences between HIV-infected patients and general population cannot be completely explained by the higher prevalence of traditional cardiovascular risk factors. We aimed to analyse the association between inflammation and subclinical atherosclerosis in HIV patients with low Framingham risk score. Materials and methods Case-control study. Setting: Outpatient Infectious Diseases clinic in a university hospital. Subjects: HIV-1-infected patients aged > 35 years receiving antiretroviral treatment with viral load < 50 copies/mL and Framingham risk score < 10%. Exclusion criteria: inflammatory diseases; dyslipidaemia requiring statins; smoking > 5 cigarettes/day; diabetes; hypertension; vascular diseases. Main outcome: subclinical atherosclerosis determined by ultrasonography: common carotid intima-media thickness greater than 0.8 mm or carotid plaque presence. Explanatory variables: ribosomal bacterial DNA (rDNA), sCD14, interleukin-6 (IL-6) and TNF-alpha. Results Eighty-four patients were included, 75% male, mean age 42 years and mean CD4+ cells 657 +/- 215/mm(3). Median Framingham risk score was 1% at 10 years (percentile 25-75: 0.5-4%). Eighteen patients (21%) had subclinical atherosclerosis; the associated factors were older age (P = 0.001), waist-hip ratio (P = 0.01), time from HIV diagnosis (P = 0.02), rDNA (P = 0.04) and IL-6 (P = 0.01). In multivariate analysis, OR for subclinical atherosclerosis was 7 (95% CI, 1.3-40, P = 0.02) and 9 (95% CI, 1.0-85, P = 0.04) for patients older than 44 years and IL-6 > 6.6 pg/mL, respectively. Conclusions Well-controlled HIV patients with low Framingham risk score have a high prevalence of subclinical carotid atherosclerosis, and the main risk factors are age and inflammation. These patients are not receiving primary prophylaxis for cardiovascular events according to current guidelines.
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