Odontogenic carcinosarcoma with dentinoid: a rare case report

Odontogenic carcinosarcoma is a very rare malignant odontogenic tumor, characterized by malignant epithelial and mesenchymal components. Studies have reported several cases of odontogenic carcinosarcoma, mainly in the upper and lower jaws, with malignant clinical manifestations. Herein, we present the case of a 58-year-old woman with odontogenic carcinosarcoma with dentinoid in the left maxilla. The invasion range was large, and the left maxillary molar was missing. Histology revealed odontogenic carcinosarcoma with bidirectional differentiation characteristics and comprising three components: malignant epithelium, malignant interstitium, and dentinoid. The patient subsequently underwent nasal endoscopic sinus tumor resection, and she recovered well after surgery. After a strict 4-year follow-up, to date, there are still no signs of disease or local recurrence. To our knowledge, this is the first reported case of odontogenic carcinosarcoma with dentinoid. Our study describes the clinical, morphological, and immunohistochemical characteristics of this case, and distinguishes it from related diseases.

Automated summary

Odontogenic carcinosarcoma is a rare malignant tumor characterized by malignant epithelial and mesenchymal components, primarily occurring in the jaws with malignant clinical manifestations. This case report describes a 58-year-old woman with odontogenic carcinosarcoma involving dentinoid in the left maxilla, who underwent successful tumor resection and showed no signs of disease or recurrence after a 4-year follow-up. This case represents the first reported instance of odontogenic carcinosarcoma with dentinoid and highlights the clinical, morphological, and immunohistochemical characteristics of this unique tumor.