Bio-inspired dynamic biomolecule assembling for fine regulation of protein activity

A versatile approach for the fine control of DNA-based hierarchical assembly via dual stimuli and two assembly strategies is developed. Moreover, with a reasonable design of functional thrombin aptamer structures on the formed DNA nanoassembly, it can achieve precise regulation of thrombin activity.

Automated summary

A versatile approach for fine control of DNA-based hierarchical assembly is developed using dual stimuli and two assembly strategies. By designing functional thrombin aptamer structures on the DNA nanoassembly, precise regulation of thrombin activity can be achieved.