4.7 Article

Multi-responsive, injectable, and self-healing hydrogels based on benzoxaborole-tannic acid complexation

期刊

POLYMER CHEMISTRY
卷 12, 期 39, 页码 5623-5630

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1py00692d

关键词

-

资金

  1. Natural Sciences and Engineering Research Council of Canada

向作者/读者索取更多资源

The plant-derived polyphenol tannic acid was used to crosslink linear statistical polymers containing benzoxaborole to form a bio-inspired, multi-responsive, injectable, and self-healing hydrogel. The mechanical properties of the hydrogel could be easily tuned by adjusting the molar ratio between tannic acid and benzoxaborole groups, and fast degradation and reversible sol-gel formation were observed under specific conditions. The hydrogel, crosslinked by dynamic boronic ester bonds, exhibited self-healing properties and injectability, making it a promising method for biomedical applications.
The plant-derived polyphenol tannic acid (TA) was used to crosslink linear statistical polymers containing benzoxaborole [poly(MPC-st-MAABO)] to form a bio-inspired, multi-responsive, injectable, and self-healing hydrogel in the physiological environment via benzoxaborole-tannic acid complexation. The mechanical properties of the hydrogel were easily tuned by adjusting the molar ratio between tannic acid and benzoxaborole groups. Fast degradation of the hydrogel was observed in the presence of fructose, adenosine 5 '-triphosphate (ATP), and dopamine (catechol), and reversible sol-gel formation was induced by changing the pH of the hydrogel. As the hydrogel was crosslinked by dynamic boronic ester bonds, the self-healing property and injectability were expected and confirmed. 3D cell encapsulation within the hydrogel scaffold was successfully achieved. This technique offered a promising method for preparing bio-inspired, multi-responsive, injectable, and self-healing hydrogels to fulfill current demands in biomedical applications.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据