Origin of enantioselectivity reversal in Lewis acid-catalysed Michael additions relying on the same chiral source

Enantiodivergence is an important concept in asymmetric catalysis that enables access to both enantiomers of a product relying on the same chiral source as reagent. This strategy is particularly appealing as an alternate approach when only one enantiomer of the required chiral ligand is readily accessible but both enantiomers of the product are desired. Despite the potential significance, general catalytic methods to effectively reverse enantioselectivity by changing an achiral reaction parameter remain underdeveloped. Herein we report our studies focused on elucidating the origin of metal-controlled enantioselectivity reversal in Lewis acid-catalysed Michael additions. Rigorous experimental and computational investigations reveal that specific Lewis and Bronsted acid interactions between the substrate and ligand change depending on the ionic radius of the metal catalyst, and are key factors responsible for the observed enantiodivergence. This holds potential to further our understanding of and facilitate the design of future enantiodivergent transformations.

Automated summary

Enantiodivergence is an important concept in asymmetric catalysis, allowing access to both enantiomers of a product when only one enantiomer of the required chiral ligand is readily available. This study focuses on elucidating the origin of metal-controlled enantioselectivity reversal, showing that specific interactions between the substrate and ligand depend on the ionic radius of the metal catalyst. This research has the potential to enhance our understanding of enantiodivergent transformations and facilitate their future design.