期刊
EUROPEAN JOURNAL OF CANCER
卷 77, 期 -, 页码 140-152出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2017.02.023
关键词
Relative survival; Europe; Cancer registries; Thyroid cancer; Papillary; EUROCARE
类别
资金
- Italian Association for Cancer Research (AIRC) [16921]
- Italian Ministry of Health [RF-2009-1529710]
- European Commission (European Action Against Cancer, EPAAC) [20102202]
- Compagnia di San Paolo [2010.1354]
- Cariplo Foundation, Italy [2010-1984]
Background: Incidence rates of thyroid cancer (TC) increased in several countries during the last 30 years, while mortality rates remained unchanged, raising important questions for treatment and follow-up of TC patients. This study updates population-based estimates of relative survival (RS) after TC diagnosis in Europe by sex, country, age, period and histology. Methods: Data from 87 cancer registries in 29 countries were extracted from the EUROCARE-5 dataset. One-and 5-year RS were estimated using the cohort approach for 86,690 adult TC patients diagnosed in 2000-2007 and followed-up to 12/31/2008. RS trends in 1999-2007 and 10-year RS in 2005-2007 were estimated using the period approach. Results: In Europe 2000-2007, 5-year RS after TC was 88% in women and 81% in men. Survival rates varied by country and were strongly correlated (Pearson rho = 75%) with country-specific incidence rates. Five-year RS decreased with age (in women from > 95% at age 15-54 to 57% at age 75+), from 98% in women and 94% in men with papillary TC to 14% in women and 12% in men with anaplastic TC. Proportion of papillary TC varied by country and increased over time, while survival rates were similar across areas and periods. In 1999-2007, 5-year RS increased by five percentage points for all TCs but only by two for papillary and by four for follicular TC. Ten-year RS in 2005-2007 was 89% in women and 79% in men. Conclusions: The reported increasing TC survival trend and differences by area are mainly explained by the varying histological case-mix of cases. (C) 2017 Elsevier Ltd. All rights reserved.
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