期刊
CHEMICAL SCIENCE
卷 12, 期 42, 页码 14121-14125出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc04475c
关键词
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资金
- National Natural Science Foundation of China [22031008]
- Science Foundation of Wuhan [2020010601012192]
- Deanship of Scientic Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia [FP-123-43]
- Ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi Arabia
The study demonstrates a new method for formation of C(sp(2))-S/Se and C(sp(2))-N bonds with isocyanides, providing access to novel multiple isothioureas and rare selenoureas. The protocol shows good atom-economy and step-economy, with theoretical calculations explaining the stereoselectivity of products. The electrochemical reaction specifically occurs at the isocyano part, regardless of the presence of radical acceptors.
The construction of C(sp(2))-X (X = B, N, O, Si, P, S, Se, etc.) bonds has drawn growing attention since heteroatomic compounds play a prominent role from biological to pharmaceutical sciences. The current study demonstrates the C(sp(2))-S/Se and C(sp(2))-N bond formation of one carbon of isocyanides with thiophenols or disulfides or diselenides and azazoles simultaneously. The reported findings could provide access to novel multiple isothioureas, especially hitherto rarely reported selenoureas. The protocol showed good atom-economy and step-economy with only hydrogen evolution and theoretical calculations accounted for the stereoselectivity of the products. Importantly, the electrochemical reaction could exclusively occur at the isocyano part regardless of the presence of susceptible radical acceptors, such as a broad range of arenes and alkynyl moieties, even alkenyl moieties.
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