期刊
HELIYON
卷 7, 期 9, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.heliyon.2021.e07933
关键词
Protein music; Sequence-to-music mapping; Amino acid properties; Musicality
资金
- National Key R&D Program of China [2019YFA0905900]
- National Natural Science Foundation of China [91856126]
- Singapore Academic Funds [R-148-000-273-114]
Protein music, inspired by analogies between protein sequences and music notes, has been composed to popularize science and source melodies. By analyzing music styles and amino acid properties, a novel protein-to-music algorithm of enhanced musicality was developed.
Inspired by the traceable analogies between protein sequences and music notes, protein music has been composed from amino acid sequences for popularizing science and sourcing melodies. Despite the continuous development of protein-to-music algorithms, the musicality of protein music lags far behind human music. Musicality may be enhanced by fine-tuned protein-to-music mapping to the features of a specific music style. We analyzed the features of a music style (Fantasy-Impromptu style), and used the quantized musical features to guide broad exploration of diverse amino acid properties (104 properties, sequence patterns and variations) for developing a novel protein-to-music algorithm of enhanced musicality. This algorithm was applied to 18 proteins of various biological functions. The derived music pieces consistently exhibited enhanced musicality with respect to existing protein music. Music style guided exploration of diverse amino acid properties enable protein music composition of enhanced musicality, which may be further developed and applied to a wider variety of music styles.
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