Copper-catalyzed regio- and stereoselective fluorocarboalkynylation of alkynes

It is attractive to establish an efficient and practical platform affording functional compounds using readily available feedstocks as starting materials under mild conditions. We describe a direct copper-catalyzed fluorocarboalkynylation of the readily available alkynes with excellent regio- and stereoselectivity. A wide range of conjugated trifluoromethyl 1,3-enynes were obtained in good yields by this operationally simple strategy. The mechanistic experiments and DFT calculation revealed that a radical-mediated process was involved in the catalytic cycle.

Automated summary

In this study, a direct copper-catalyzed fluorocarboalkynylation of readily available alkynes was achieved with good yields and operational simplicity. Mechanistic experiments and DFT calculations indicated the involvement of a radical-mediated process in the catalytic cycle.