期刊
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
卷 15, 期 -, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/17534666211049735
关键词
anti-interleukin 5; anti-interleukin 5 receptor; failure; severe asthma
This study achieved an expert consensus in defining failure criteria for anti-interleukin 5/R treatment in severe asthma patients. The study proposed objective criteria for treatment failure and provided guidelines for prescription, evaluation, and discontinuation decision-making. These criteria and guidelines can help physicians tailor treatment plans more effectively for severe asthma patients.
Background: Current practices for assessing response to anti-interleukin 5/R treatment in severe asthma patients are heterogeneous. The objective of this study was to achieve an expert consensus defining failure criteria for anti-interleukin 5/R treatment in severe asthma patients. Methods: Experts were invited to a 5-round Delphi exercise if they were pulmonologists managing > 30 patients at a nationally recognized severe asthma expert centre. Following two rounds of statement-generating brainstorming, the expert panel ranked each statement according to a 5-point Likert-type scale during three additional rounds. Positive consensus was considered achieved when > 80% of experts agreed with a statement with >50% strong agreement and Results: Twenty experts participated in the study. All experts agreed that predefined treatment goals defining effectiveness should be personalized during shared decision making via a patient contract. Treatment failure was defined as (1) absence of a reduction in exacerbation rates by > 25% or (2) absence of a reduction in oral corticosteroid therapy by > 25% of the initial dosage or (3) occurrence of emergency room visits or hospitalizations after 6 months of treatment. Treatment failure should result in discontinuation. For partial responders, treatment discontinuation was not recommended unless an alternative from another therapeutic class exists and should be discussed in a multidisciplinary consultation. Conclusion: The present study provides objective criteria for anti IL5 or IL5R failure in severe asthma and suggests consensus based guidelines for prescription, evaluation and discontinuation decision-making.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据