4.2 Article

Increased Infections and Delayed CD4+ T Cell but Faster B Cell Immune Reconstitution after Post-Transplantation Cyclophosphamide Compared to Conventional GVHD Prophylaxis in Allogeneic Transplantation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide

Benedetta Rambaldi et al.

Summary: Administration of posttransplant cyclophosphamide has increased the number of patients undergoing HLA-haploidentical hematopoietic cell transplantation. Immune reconstitution in haplo-HCT patients showed delayed T-cell recovery skewed towards effector memory T cells and higher regulatory T cell ratios early after transplant. NK cell reconstitution also differed, with increased immature NK cells and enrichment of specific NK cell metadusters after haplo-HCT.

BLOOD ADVANCES (2021)

Article Hematology

Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis

Scott R. Goldsmith et al.

Summary: This study analyzed the impact of graft source and posttransplant cyclophosphamide (PTCy) on CMV infection, finding a higher risk of CMV infection in PTCy recipients, regardless of donor. CMV infection may also affect transplant outcomes.
Article Biophysics

Patterns of infection and infectious-related mortality in patients receiving post-transplant high dose cyclophosphamide as graft-versus-host-disease prophylaxis: impact of HLA donor matching

Garcia-Cadenas Irene et al.

Summary: The study found that patients undergoing allogeneic hematopoietic stem cell transplant (allo-SCT) with post-transplant cyclophosphamide (PTCy) are at risk for infections, especially with a higher incidence of early viral infections in haploidentical transplant recipients. However, the mortality rate from severe infections is low and similar across all donor types.

BONE MARROW TRANSPLANTATION (2021)

Article Medicine, Research & Experimental

Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression

Lucas P. Wachsmuth et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Biophysics

Halfway there: the past, present and future of haploidentical transplantation

M. Slade et al.

BONE MARROW TRANSPLANTATION (2017)

Article Medicine, General & Internal

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation

F. M. Marty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cell Biology

Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide

Christopher G. Kanakry et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Meeting Abstract Hematology

Memory B cells protect from CMV infection in the absence of T cells.

Thomas H. Winkler et al.