期刊
NATURE METABOLISM
卷 3, 期 10, 页码 1302-1312出版社
NATURE PORTFOLIO
DOI: 10.1038/s42255-021-00470-z
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资金
- Welcome Trust [206453/Z/17/Z]
- UK National Institute for Health Research Southampton Biomedical Research Centre
- US National Institutes of Health [DK123458, HL125753]
- Juvenile Diabetes Research Foundation
- Lab1636
- Wellcome Trust [206453/Z/17/Z] Funding Source: Wellcome Trust
This review focuses on tumor necrosis factor (TNF) in the context of metabolic inflammation, highlighting its immunometabolic actions and relevance to other pro-inflammatory signals and metabolic diseases. It presents a conceptual framework applicable to the complex network of pro-inflammatory signals and their integration with metabolic regulation.
Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also the first 'adipokine' described to be produced from adipose tissue, regulated in obesity and proposed to contribute to obesity-associated metabolic disease. In this review, we provide an overview of TNF in the context of metabolic inflammation or metaflammation, its discovery as a metabolic messenger, its sites and mechanisms of action and some critical considerations for future research. Although we focus on TNF and the studies that elucidated its immunometabolic actions, we highlight a conceptual framework, generated by these studies, that is equally applicable to the complex network of pro-inflammatory signals, their biological activity and their integration with metabolic regulation, and to the field of immunometabolism more broadly. Tumour necrosis factor is a classical pro-inflammatory cytokine. Sethi and Hotamisligil provide a comprehensive overview of its pleiotropic immunometabolic actions, while presenting a framework that is applicable to the complex network of other pro-inflammatory signals and their relevance to metabolic diseases such as obesity and diabetes.
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