期刊
NANOSCALE
卷 13, 期 45, 页码 19085-19097出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nr05508a
关键词
-
类别
资金
- Zhejiang Provincial Natural Science Foundation [LGF21H180005]
- Science and Technology Plan in Shaoxing City [2018C10011]
- College Students' Science and Technology Innovation Project of Zhejiang Province [2020R444018]
- National College Students Innovation and Entrepreneurship Training Program, China [201910349039X, 202010349004, 202010349051X]
- Medical and Health Science and Technology Plan Project of Zhejiang Province [2021KY1159]
- Medical and Health Science and Technology Plan Project of Shaoxing [2020A13024, 2020A13060]
The PPy@BSA-MnO2 nanoprobes demonstrated excellent effectiveness in killing breast cancer cells and inhibiting tumor growth, as well as significant advantages in MRI-guided photothermal/chemodynamic synergistic therapy for breast cancer treatment.
Polypyrrole (PPy) nanoparticles have been widely studied in tumor photothermal therapy (PTT) for their significant photostability, good biocompatibility, and excellent photothermal performance. Herein, we report bovine serum albumin (BSA) stabilized PPy that were mineralized by MnO2 nanozyme on the surface (PPy@BSA-MnO2) to achieve synergistic photothermal and chemodynamic therapy (CDT) for breast cancer. In this multifunctional nanoplatform, the surface-loaded MnO2 undergoes a redox reaction with glutathione (GSH) to generate glutathione disulfide (GSSG) and Mn2+. Then, Mn2+ can convert H2O2 into a highly cytotoxic OH to achieve chemodynamic therapy (CDT) and possess good magnetic resonance (MR) T-1-weighted imaging capabilities to realize contrast imaging of the 4T1 tumor-bearing mouse models. In addition, PPy nanoparticles can efficiently convert near-infrared light energy into heat and achieve PTT. Most importantly, PPy@BSA-MnO2 nanoprobes have excellent in vitro 4T1 cell-killing effect and in vivo tumor-suppressive properties. The acute toxicity assessment results indicate that PPy@BSA-MnO2 nanoprobes have good biological safety. Therefore, the as-prepared multifunctional PPy@BSA-MnO2 nanoprobes possess excellent performance to promote MRI-guided PTT/CDT synergistic therapy for breast cancer treatment and have extensive clinical transformation and application prospects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据