期刊
GENOME BIOLOGY
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13059-021-02512-x
关键词
Genome assembly; Haplotype; Diploid; Long reads
资金
- Chinese Scholarship Council
- Dutch Scientific Organization, through Vidi grant [639.072.309]
- European Union [956229, 872539]
- Projekt DEAL
Haplotype-aware diploid genome assembly is essential in various disciplines, and phasebook, a novel de novo approach, outperforms other methods in terms of haplotype coverage while maintaining competitive performance in assembly errors and contiguity.
Haplotype-aware diploid genome assembly is crucial in genomics, precision medicine, and many other disciplines. Long-read sequencing technologies have greatly improved genome assembly. However, current long-read assemblers are either reference based, so introduce biases, or fail to capture the haplotype diversity of diploid genomes. We present phasebook, a de novo approach for reconstructing the haplotypes of diploid genomes from long reads. phasebook outperforms other approaches in terms of haplotype coverage by large margins, in addition to achieving competitive performance in terms of assembly errors and assembly contiguity.
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