期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 16, 期 4, 页码 397-418出版社
SHENYANG PHARMACEUTICAL UNIV
DOI: 10.1016/j.ajps.2020.10.002
关键词
Mitochondrial targeting; Cancer; Nanocarriers; Photodynamic therapy; Photothermal therapy
资金
- Department of Science and Technology
- SERB (INSPIRE Grant) [IFA-LSBM-13, EMR/2016/007966/HS]
- Ministry of Chemicals and Fertilizer
Nanotechnology has shown tremendous potential in cancer therapy by targeting mitochondria, the powerhouse of the cell, and different nanoparticulate systems have been explored for improving the treatment of cancer by targeting mitochondria.
Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cancer therapy due to its specificity. In cancer, several targets have been explored which could be utilized for the better treatment of disease. Mitochondria, the so-called powerhouse of cell, portrays significant role in the survival and death of cells, and has emerged as potential target for cancer therapy. Direct targeting and nanotechnology based approaches can be tailor-made to target mitochondria and thus improve the survival rate of patients suffering from cancer. With this backdrop, in present review, we have reemphasized the role of mitochondria in cancer progression and inhibition, highlighting the different targets that can be explored for targeting of disease. Moreover, we have also summarized different nanoparticulate systems that have been used for treatment of cancer via mitochondrial targeting. (C) 2020 Shenyang Pharmaceutical University. Published by Elsevier B.V.
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