Nuclear PHGDH protects cancer cells from nutrient stress

In this study, the serine biosynthetic enzyme PHGDH is shown to transition from the cytosol to the nucleus following nutrient stress. Nuclear PHGDH reduces local NAD(+) availability needed for the PARylation of the transcription factor c-Jun. Consequently, c-Jun activity is reduced, contributing to sustained cancer cell proliferation.

Automated summary

The study demonstrates the transition of PHGDH to the nucleus following nutrient stress, impacting the activity of c-Jun and contributing to sustained cancer cell proliferation.