☆ 4.1 Review

Efficacy of Sacubitril/Valsartan in the Setting of Acute Heart Failure: A Systematic Review

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Summary: Despite high adherence to contemporary practice guidelines, short-term mortality and rehospitalization rates remain high for patients admitted for acute heart failure (AHF). Non-randomized studies support the use of evidence-based chronic heart failure medications during hospitalization to reduce morbidity and mortality. However, the implementation of sacubitril/valsartan during hospitalization is suboptimal due to various challenges, including a lack of integrated individualized plans and uncertainty about patient eligibility.

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