期刊
NATURE COMPUTATIONAL SCIENCE
卷 1, 期 11, 页码 754-766出版社
SPRINGERNATURE
DOI: 10.1038/s43588-021-00154-4
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资金
- ARC [DP160102644]
Off-lattice models are an established approach in multicellular modeling, representing cells as points free to move in space. A new off-lattice modeling framework using rigid body mechanics to represent objects as conjoined one-dimensional edges in a viscosity-dominated system has been introduced, offering solutions to limitations in current off-lattice multicellular models. This framework allows for representation of cells as free moving polygons, interactions of epithelial layers, modeling of rod-shaped cells like bacteria, and robust representation of membranes.
Off-lattice models are a well-established approach in multicellular modeling, where cells are represented as points that are free to move in space. The representation of cells as point objects is useful in a wide range of settings, particularly when large populations are involved; however, a purely point-based representation is not naturally equipped to deal with objects that have length, such as cell boundaries or external membranes. Here we introduce an off-lattice modeling framework that exploits rigid body mechanics to represent objects using a collection of conjoined one-dimensional edges in a viscosity-dominated system. This framework can be used to represent cells as free moving polygons, to allow epithelial layers to smoothly interact with themselves, to model rod-shaped cells such as bacteria and to robustly represent membranes. We demonstrate that this approach offers solutions to the problems that limit the scope of current off-lattice multicellular models.
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