Metal-free synthesis of 3-sulfonyl-5-selanyl-4a,8a-dihydro- 2H-chromen-6(5H)-ones via visible light driven intermolecular cascade cyclization of alkyne-tethered cyclohexadienones and selenosulfonates

A metal-free and efficient visible-light induced cascade cyclization of alkyne-tethered cyclohexadienones with selenosulfonates for the synthesis of 3-sulfonyl-5-selanyl-4a,5-dihydro-2H-chromen-6(8aH)-one in good to excellent yields has been developed, in which three new stereocenters are formed and both sulfone and selenyl groups are simultaneously introduced.

Automated summary

A metal-free and efficient visible-light induced cascade cyclization of alkyne-tethered cyclohexadienones with selenosulfonates has been developed for the synthesis of 3-sulfonyl-5-selanyl-4a,5-dihydro-2H-chromen-6(8aH)-one in good to excellent yields, forming three new stereocenters and introducing both sulfone and selenyl groups simultaneously.