期刊
SMALL STRUCTURES
卷 2, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/sstr.202100110
关键词
cancer combination therapy; multimodal imaging; photothermal agents; photothermal therapy; polymers
资金
- NNSF of China [61775095, 61935004]
- Jiangsu Province Policy Guidance Plan [BZ2019014]
- Six talent peak innovation team of Jiangsu Province [TD-SWYY-009]
- Natural Science Foundation of Shandong Province [ZR2020KB018]
- Taishan scholars construction special fund of Shandong Province
Scientists have made significant efforts in cancer control, with photothermal therapy (PTT) emerging as a promising treatment method. Polymer-based PTAs play a crucial role in cancer diagnosis and therapy, offering various advantages in terms of design, synthesis, biocompatibility, and therapeutic effects.
Significant efforts have been made on cancer control by scientists. And various methods for cancer treatment are constantly emerging. Among them, photothermal therapy (PTT) has received a wide range of attention due to its special features, including noninvasiveness, remote control, high selectivity, negligible drug resistance, insignificant side effects, and desired therapeutic effects. Photothermal agents (PTAs), which can convert light into heat under laser irradiation, serve as a crucial role during PTT for killing cancer cells. In the past decades, different kinds of PTAs have been successfully developed. Among these, polymer-based PTAs are widely used in cancer diagnosis and PTT owing to their competitive features, including customizable designs, controllable synthesis, excellent biocompatibility, negligible cytotoxicity, satisfactory photostability, and desirable photothermal effects. In addition, along with PTT, they also play a crucial role in tumor targeting, cancer imaging, drug delivery, and combination therapies. Herein, the recent advances in cancer therapeutic nanoplatforms built on polymers are reviewed in detail. Meanwhile, future opportunities and challenges for polymer-based PTAs in cancer therapy are also exemplified.
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