期刊
MOLECULAR BIOLOGY
卷 55, 期 5, 页码 705-726出版社
PLEIADES PUBLISHING INC
DOI: 10.1134/S0026893321040075
关键词
guanine quadruplexes; G4; DNA; RNA; nucleic acid secondary structure; regulation of gene expression
G-quadruplexes are dynamic structures whose stability depends on various factors, and they play a crucial role in multiple processes in DNA and RNA.
Cell metabolism depends, to a large extent, on correct regulation of gene expression. One of the mechanisms of regulation is the formation of nucleic acid secondary structures, among which guanine quadruplexes (G-quadruplexes, or G4) are of particular importance. G-quadruplexes are dynamic structures whose stability is determined by their size, ionic composition, and the nature of the nucleic acids forming them. They are regulated by various protein factors. Guanine quadruplexes play an important role in the regulation of many processes occurring in DNA and RNA, from maintaining telomere homeostasis to determining the ribosome landing site on mRNA. Therefore, these structures are considered a promising target for antitumor therapy, and their detailed study is important to modern biology. This review is focused on the structure and thermodynamic properties of G-quadruplexes together with their interaction with some nuclear proteins.
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