期刊
CHEMICAL SOCIETY REVIEWS
卷 50, 期 23, 页码 13012-13089出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cs00137j
关键词
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资金
- Science and Engineering Research Board - Department of Science and Technology (SERB - DST), India [PDF/2018/000079]
- Department of Science and Technology (DST), India
- Indo-German Science and Technology Centre (IGSTC), New Delhi [IGSTC/Call 2015-Extension/Multi-WAP/09/2019-20]
- CERCA programme, Generalitat de Catalunya
- Severo Ochoa Centres of Excellence programme - Spanish Research Agency (AEI) [SEV-2017-0706]
This review discusses the design and development of high-performance biosensing modalities for detecting ultra-low abundance of analytes in real-life samples. It focuses on Attomolar Analyte Sensing Techniques (AttoSens) that provide relevant sensitivity, selectivity, response time, and sampling efficiency. The summary highlights the technological advances made in the past decade by AttoSens trends for detecting attomolar concentration of analytes.
Detecting the ultra-low abundance of analytes in real-life samples, such as biological fluids, water, soil, and food, requires the design and development of high-performance biosensing modalities. The breakthrough efforts from the scientific community have led to the realization of sensing technologies that measure the analyte's ultra-trace level, with relevant sensitivity, selectivity, response time, and sampling efficiency, referred to as Attomolar Analyte Sensing Techniques (AttoSens) in this review. In an AttoSens platform, 1 aM detection corresponds to the quantification of 60 target analyte molecules in 100 mu L of sample volume. Herein, we review the approaches listed for various sensor probe design, and their sensing strategies that paved the way for the detection of attomolar (aM: 10(-18) M) concentration of analytes. A summary of the technological advances made by the diverse AttoSens trends from the past decade is presented.
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