A multifunctional divergent scaffold to access the formal syntheses of various sesquiterpenoids

The development of a divergent scaffold able to access an array of diverse natural sesquiterpenoids is described. The route unifies the scope of previously reported plans of our group to allow the scalable synthesis of 8,12-furo and lactone sesquiterpenoid carbocyclic cores of elemanes, germacranes, guaianes, cadinanes, lindenanes and myliols. The formal syntheses of furogermenone, methyl-curdionolide, zedoarol, qweicurculactone, lindenene and sarcandralactone A are reported.

Automated summary

This study describes the development of a divergent scaffold for accessing diverse natural sesquiterpenoids. The method allows scalable synthesis of various sesquiterpenoid carbocyclic cores and reports formal syntheses of several compounds.