期刊
BIORESOURCES AND BIOPROCESSING
卷 8, 期 1, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1186/s40643-021-00461-8
关键词
Trichoderma reesei; Cellulase; beta-Glucosidase; Transporter; Induction; Transcription factor; Environmental factor; Secretion
资金
- National Key Research and Development Program of China [2021YFC2100203]
- National Natural Science Foundation of China [32072162]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_1819]
- National First-Class Discipline Program of Light Industry Technology and Engineering [LITE2018-09]
- 111Project [111-2-06]
The review summarizes recent progress in cellulase production of the filamentous fungus Trichoderma reesei, highlighting key factors such as carbon source-dependent induction, transcriptional regulation, and protein assembly. These findings shed light on potential directions for further engineering.
The filamentous fungus Trichoderma reesei has been widely used for cellulase production that has extensive applications in green and sustainable development. Increasing costs and depletion of fossil fuels provoke the demand for hyper-cellulase production in this cellulolytic fungus. To better manipulate T. reesei for enhanced cellulase production and to lower the cost for large-scale fermentation, it is wise to have a comprehensive understanding of the crucial factors and complicated biological network of cellulase production that could provide new perspectives for further exploration and modification. In this review, we summarize recent progress and give an overview of the cellular process of cellulase production in T. reesei, including the carbon source-dependent cellulase induction, complicated transcriptional regulation network, and efficient protein assembly and trafficking. Among that, the key factors involved in cellulase production were emphasized, shedding light on potential perspectives for further engineering.
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