期刊
NATURAL PRODUCT REPORTS
卷 38, 期 11, 页码 2100-2129出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1np00032b
关键词
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资金
- US National Institutes of Health [F31-HD101307, R01-GM085770]
- University of North Carolina at Greensboro
- National Center for Complementary and Integrative Health, a component of the US National Institutes of Health [T32AT008938]
With the availability of genetic information for hundreds of thousands of organisms in publicly accessible databases, scientists have unprecedented opportunities to explore the diversity and inner workings of life. By harnessing this information, researchers are able to specifically discover bioactive natural products and their gene clusters using orthogonal genome mining strategies.
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of organisms in publicly accessible databases, scientists have an unprecedented opportunity to meticulously survey the diversity and inner workings of life. The natural product research community has harnessed this breadth of sequence information to mine microbes, plants, and animals for biosynthetic enzymes capable of producing bioactive compounds. Several orthogonal genome mining strategies have been developed in recent years to target specific chemical features or biological properties of bioactive molecules using biosynthetic, resistance, or transporter proteins. These biosynthetic hooks allow researchers to query for biosynthetic gene clusters with a high probability of encoding previously undiscovered, bioactive compounds. This review highlights recent case studies that feature orthogonal approaches that exploit genomic information to specifically discover bioactive natural products and their gene clusters.
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