Global public health security and justice for vaccines and therapeutics in the COVID-19 pandemic

Article Biochemistry & Molecular Biology

A global survey of potential acceptance of a COVID-19 vaccine

Jeffrey V. Lazarus et al.

Summary: Survey data from 19 countries reveals varying attitudes towards acceptance of a COVID-19 vaccine, with trust in government being linked to vaccine confidence.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Looking beyond COVID-19 vaccine phase 3 trials

Jerome H. Kim et al.

Summary: Following the announcement of COVID-19 vaccine efficacy in clinical trials, a comprehensive strategy is needed for global vaccination, including manufacturing, support, supply coordination, equitable distribution, and logistics. Additionally, addressing scientific questions to improve vaccine efficacy is crucial for ending the pandemic effectively and efficiently.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

R. Libster et al.

Summary: A randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against SARS-CoV-2 in older adult patients within 72 hours after the onset of mild Covid-19 symptoms found that early administration of high-titer convalescent plasma reduced the progression of Covid-19 in mildly ill infected older adults.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Medicine, General & Internal

The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis

Stephen A. Klassen et al.

Summary: Studies show that COVID-19 convalescent plasma can lower mortality rates in patients, especially when administered early and with higher antibody titers.

MAYO CLINIC PROCEEDINGS (2021)

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Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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News Item Medicine, General & Internal

COVID-19 Vaccines vs Variants-Determining How Much Immunity Is Enough

Rita Rubin

Summary: Efficiency of COVID-19 vaccines against SARS-CoV-2 variants is still being studied.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Editorial Material Multidisciplinary Sciences

COVID vaccines: time to confront anti-vax aggression

Peter Hotez

Summary: To halt the spread of the coronavirus, a high-level counteroffensive against new destructive forces is necessary.

NATURE (2021)

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Review Biochemistry & Molecular Biology

Existing Drugs Considered as Promising in COVID-19 Therapy

Edyta Janik et al.

Summary: COVID-19 is a respiratory disease caused by SARS-CoV-2, for which finding effective drugs remains a urgent target for the global scientific community. The pathogenesis is mainly related to virus replication and excessive immune/inflammatory response. Treatment options include antiviral and immunomodulatory/anti-inflammatory agents.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Editorial Material Medicine, General & Internal