4.6 Review

Combatting Helicobacter pylori with oral nanomedicines

期刊

JOURNAL OF MATERIALS CHEMISTRY B
卷 9, 期 48, 页码 9826-9838

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb02038b

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资金

  1. National Key Research and Development Program of China [2019YFA0111300]
  2. National Natural Science Foundation of China [51903256, 21907113, 32001012]
  3. Guangdong Provincial Science and Technology Program (International Scientific Cooperation) [2018A050506035]
  4. Science and Technology Program of Guangzhou [20210 2010225, 202102010217]
  5. Natural Science Foundation of Guangdong Province [2019A151501141]
  6. China Postdoctoral Science Foundation [2020M683060]
  7. Talent Introduction Program of Postdoctoral International Exchange Program [YJ20200313]
  8. Thousand Talents Plan
  9. Guangdong Provincial Pearl River Talents Program [2019QN01Y131]

向作者/读者索取更多资源

H. pylori infection is the main cause of most digestive diseases, and traditional oral medication is limited in its efficacy, while nanomedicine offers efficient and effective targeted drug delivery solutions.
Helicobacter pylori (H. pylori) infection is considered to be the main cause of most digestive diseases,such as chronic active gastritis, gastroduodenal ulcers, or even gastric cancer. Oral medication is a transformative approach to treat H. pylori-induced infections. However, unlike intravenous administration, orally administrated drugs have to overcome various barriers before reaching the infected sites, which significantly limits the therapeutic efficacy. These challenges may be addressed by emerging nanomedicine that is equipped with nanotechnology approaches to enable efficient and effective targeted delivery of drugs. Herein, in this review, we first discuss the conventional therapy for the eradication of H. pylori. Through the introduction of the critical barriers of oral administration, the benefits of nanomedicine are highlighted. Recently-published examples of nanocarriers for combating H. pylori in terms of design, preparation, and antimicrobial mechanisms are then presented, followed by our perspective on potential future research directions of oral nanomedicines.

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