The emerging role of neutrophils in autoimmune-associated disorders: effector, predictor, and therapeutic targets

Neutrophils are essential components of the immune system and have vital roles in the pathogenesis of autoimmune disorders. As effector cells, neutrophils promote autoimmune disease by releasing cytokines and chemokines cascades that accompany inflammation, neutrophil extracellular traps (NETs) regulating immune responses through cell-cell interactions. More recent evidence has extended functions of neutrophils. Accumulating evidence implicated neutrophils contribute to tissue damage during a broad range of disorders, involving rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary sjogren's syndrome (pSS), multiple sclerosis (MS), crohn's disease (CD), and gout. A variety of studies have reported on the functional role of neutrophils as therapeutic targets in autoimmune diseases. However, challenges and controversies in the field remain. Enhancing our understanding of neutrophils' role in autoimmune disorders may further advance the development of new therapeutic approaches.

Automated summary

Neutrophils are essential components of the immune system and play crucial roles in the pathogenesis of autoimmune diseases by promoting inflammation and regulating immune responses through cell-cell interactions. Recent studies have implicated neutrophils in tissue damage across a broad range of disorders, highlighting their potential as therapeutic targets in autoimmune diseases. Further research into the role of neutrophils in autoimmune disorders may lead to the development of new therapeutic approaches.