4.6 Article

A novel characterisation approach to reveal the mechano-chemical effects of oxidation and dynamic distension on polypropylene surgical mesh

期刊

RSC ADVANCES
卷 11, 期 55, 页码 34710-34723

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra05944k

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资金

  1. EPSRC [EP/N008065/1, EP/R513313/1, EP/T517835/1]
  2. German Federal Ministry of Education and Research [03Z22D511]
  3. EPSRC [EP/N008065/1] Funding Source: UKRI

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Polypropylene (PP) surgical mesh, successful in abdominal hernia repair, can lead to serious clinical complications when used for stress urinary incontinence or pelvic organ prolapse repair in the pelvic floor; evidence suggests that PP fibers are susceptible to oxidative damage and play a role in causing complications. The specific host response mechanisms against the material remain poorly understood.
Polypropylene (PP) surgical mesh, used successfully for the surgical repair of abdominal hernias, is associated with serious clinical complications when used in the pelvic floor for repair of stress urinary incontinence or support of pelvic organ prolapse. While manufacturers claim that the material is inert and non-degradable, there is a growing body of evidence that asserts PP fibres are subject to oxidative damage and indeed explanted material from patients suffering with clinical complications has shown some evidence of fibre cracking and oxidation. It has been proposed that a pathological cellular response to the surgical mesh contributes to the medical complications; however, the mechanisms that trigger the specific host response against the material are not well understood. Specifically, this study was constructed to investigate the mechano-chemical effects of oxidation and dynamic distension on polypropylene surgical mesh. To do this we used a novel advanced spectroscopical characterisation technique, secondary electron hyperspectral imaging (SEHI), which is based on the collection of secondary electron emission spectra in a scanning electron microscope (SEM) to reveal mechanical-chemical reactions within PP meshes.

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