Tuning the organelle specificity and cytotoxicity of iridium(iii) photosensitisers for enhanced phototheranostic applications

Luminescent cyclometallated iridium(iii) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.

Automated summary

The luminescent cyclometallated iridium(iii) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents, displaying tunable organelle-targeting properties, minimal dark cytotoxicity, and substantial photocytotoxicity even under hypoxic conditions.