期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 23, 期 43, 页码 24757-24764出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cp03617c
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资金
- Universite de Lorraine
- CNRS
- European Union European Regional Development Funds (Programme operationnel FEDER-FSE Lorraine et Massif des Vosges 2014-2020Fire Light'' project: Photo-bio-active molecules and nanoparticles'')
- ANR (Agence Nationale de la Recherche)
- CGI (Commissariat a` l'Investissement d'Avenir) through Labex SEAM (Science and Engineering for Advanced Materials and devices) [ANR 11 LABX 086, ANR 11 IDEX 05 02]
The study found that while hydrogen transfer in curcumin is extremely fast, occurring in the sub-ps regime, intersystem crossing is still present, as shown by the non-negligible population of the triplet state manifold after 2 ps.
Curcumin is a natural compound extracted from turmeric (Curcuma longa), which has shown remarkable anti-inflammatory, antibacterial, and possibly anticancer properties. The intense absorption in the visible domain and the possibility of intersystem crossing make curcumin attractive also for photodynamic therapy purposes. In the present contribution, we unravel, thanks to non-adiabatic surface hopping dynamics, the interplay between intersystem crossing and hydrogen transfer in the enol form, i.e. the most stable tautomer of curcumin. Most notably, we show that while hydrogen transfer is ultrafast and happens in the sub-ps regime, intersystem crossing is still present, as shown by the non-negligible population of the triplet state manifold after 2 ps. Hence, while the hydrogen transfer channel can act as a deactivating channel, curcumin, also in the red-shifted absorption enol form, can still be regarded as potentially favorable for photodynamic therapy applications.
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