期刊
ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS
卷 15, 期 1, 页码 1645-1665出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/19942060.2021.1984993
关键词
Carotid stenosis (CS); circle of Willis (CoW); pulsatility index (PI); resistive index (RI); time to peak velocity (TPV); regression model
资金
- Korea Institute of Energy Technology Evaluation and Planning (KETEP)
- Ministry of Trade, Industry & Energy (MOTIE) of the Republic of Korea [20214000000280]
- MSIT (Ministry of Science and ICT), Korea, under the ITRC (Information Technology Research Center) support program [IITP-2020-2020-0-01655]
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2019R1A2C1087763]
- National Research Foundation of Korea [2019R1A2C1087763] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study numerically investigated the hemodynamic correlations during the progression of carotid stenosis. The results showed that as stenosis progressed, time to peak velocity increased and was negatively correlated with PI, RI, and Re-Mean in the ipsilateral cerebral region. Additionally, PI and RI in cerebral arteries exhibited three distinct regression patterns.
Haemodynamic correlations among the pulsatility index (PI), resistive index (RI), time to peak velocity (TPV), and mean Reynolds number (Re-Mean) were numerically investigated during the progression of carotid stenosis (CS), a highly prevalent condition. Fifteen patient-specific CS cases were modeled in the package, SimVascular, by using computed tomography angiography data for the aortic-cerebral vasculature. Computational fluid domains were solved with a stabilized Petrov-Galerkin scheme under Newtonian and incompressible assumptions. A rigid vessel wall was assumed, and the boundary conditions were pulsatile inflow and three-element lumped Windkessel outlets. During the progression, the increase in the TPV resembled that during aortic stenosis, and the parameter was negatively correlated with PI, RI, and Re-Mean in the ipsilateral cerebral region. The Re-Mean was inversely related to PI and RI on the contralateral side. In particular, PI and RI in cerebral arteries showed three second-order regression patterns: 'constant (Group A)', 'moderately decreasing (Group B)', and 'decreasing (Group C)'. The patterns were defined using a new parameter, mean ratio (lowest mean index/mean index at 0% CS). This parameter could effectively indicate stenosis-driven tendencies in local haemodynamics. Overall, the haemodynamic indices changed drastically during severe unilateral CS, and they reflected both regional and aortic-cerebral flow characteristics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据