期刊
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 3, 页码 401-404出版社
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/ceji.2021.109670
关键词
drug-induced hypersensitivity syndrome; drug reaction with eosinophilia and systemic symptoms; second-line treatment for tuberculosis
类别
DiHS/DRESS is a severe adverse drug-induced reaction characterized by various symptoms, with mechanisms involving genetic susceptibility, detoxification defects, and viral reactivation. Common causes include antiepileptic drugs, allopurinol, and sulfonamides. Patch testing can be helpful in diagnosing and evaluating this syndrome.
Drug-induced hypersensitivity syndrome (DiHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe adverse drug-induced reaction characterized by various symptoms: skin rash, fever, lymph node enlargement and internal organ involvement, which starts within 2 weeks to 3 months after drug initiation. It is challenging to diagnose this syndrome due to the variety of cutaneous and visceral symptoms. Different mechanisms have been implicated in its development, including genetic susceptibility associated with human leucocyte antigen (HLA) loci, detoxification defects leading to reactive metabolite formation and subsequent immunological reactions, slow acetylation, and reactivation of human herpes, including Epstein-Barr virus and human herpes virus (HHV)-6 and HHV-7. The most frequently reported causes of DiHS/DRESS are antiepileptic agents, allopurinol and sulfonamides. We report a case of DiHS/DRESS induced by second-line treatment for tuberculosis, prothionamide and para-aminosalicylic acid, and Epstein-Barr virus re-infection. Patch testing, which was performed in this case, is not fully standardized, but it can be helpful and a safe way to evaluate and diagnose DiHS/DRESS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据