期刊
LAB ON A CHIP
卷 21, 期 23, 页码 4574-4585出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1lc00602a
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Research Chair program
- Michael Smith Foundation for Health Research Scholar program
- Pacific Alzheimer Research Foundation
- Canada Foundation for Innovation John R. Evans Leaders Fund (CFI-JELF)
- British Columbia Knowledge Development Fund (BCKDF)
- NSERC Research Tools and Instruments program
- University of Bristol
- EPSRC New Investigator Award [EP/T01508X/1]
- EPSRC [EP/T01508X/1] Funding Source: UKRI
Researchers have designed a microfluidic platform for building bespoke prototissues from predetermined compositions of two types of protein-polymer protocells. They demonstrate control over the collective behaviors and endogenous biochemical reactivity of the biomaterial, offering a new route for high-throughput fabrication of tissue-like materials with programmable collective properties.
The precise assembly of protocell building blocks into prototissues that are stable in water, capable of sensing the external environment and which display collective behaviours remains a considerable challenge in prototissue engineering. We have designed a microfluidic platform that enables us to build bespoke prototissues from predetermined compositions of two types of protein-polymer protocells. We can accurately control their size, composition and create unique Janus configurations in a way that is not possible with traditional methods. Because we can control the number and type of the protocells that compose the prototissue, we can hence modulate the collective behaviours of this biomaterial. We show control over both the amplitude of thermally induced contractions in the biomaterial and its collective endogenous biochemical reactivity. Our results show that microfluidic technologies enable a new route to the precise and high-throughput fabrication of tissue-like materials with programmable collective properties that can be tuned through careful assembly of protocell building blocks of different types. We anticipate that our bespoke prototissues will be a starting point for the development of more sophisticated artificial tissues for use in medicine, soft robotics, and environmentally beneficial bioreactor technologies.
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