4.7 Article

Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA

Yuze Wang et al.

Summary: The study identified SAMD4A as a key gene in suppressing HBV replication by triggering degradation through specific RNA binding, highlighting its potential significance in hepatitis B therapy.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Gastroenterology & Hepatology

Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian patients with chronic hepatitis B suitable for entecavir cessation

Wai-Kay Seto et al.

Summary: In patients with chronic HBV infection, measurement of serum HBV RNA is crucial in determining the suitability of cessation of entecavir treatment, especially for those with low HBsAg levels. Patients can be stratified based on viral determinants to assess their risk of off-treatment relapse.
News Item Biotechnology & Applied Microbiology

Restoring IL-2 to its cancer immunotherapy glory

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Immunology

Pegylated Interferon-α (IFN-α) Enhances the Inhibitory Effect of Natural Killer Cells on Regulatory T Cells via IFN-γ in Chronic Hepatitis B

Wei Yuan et al.

Summary: The study reveals that NK cells can suppress the proliferation and differentiation of Tregs by secreting IFN-gamma in both CHB patients and HBV-carrier mouse model. Additionally, PegIFN-alpha treatment can enhance this inhibition and lead to more vigorous HBV-specific T-cell responses and marked reduction in HBsAg levels.

JOURNAL OF INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Efficacy of a combination of HBV RNA and HBeAg in predicting HBeAg seroconversion in patients treated with entecavir for 144 weeks

Xiaomei Wang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Review Immunology

Shared and Distinct Functions of Type I and Type III Interferons

Helen M. Lazear et al.

IMMUNITY (2019)

Article Medicine, Research & Experimental

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Aimee Merino et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Gastroenterology & Hepatology

Insights From Antiviral Therapy Into Immune Responses to Hepatitis B and C Virus Infection

Barbara Rehermann et al.

GASTROENTEROLOGY (2019)

Article Medicine, Research & Experimental

Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation

Laura Rivino et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Virology

Perspectives and limitations for nucleo(t)side analogs in future HBV therapies

Massimo Levrero et al.

CURRENT OPINION IN VIROLOGY (2018)

Article Medicine, Research & Experimental

PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection

Loghman Salimzadeh et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Immunology

Biology and regulation of IL-2: from molecular mechanisms to human therapy

Rosanne Spolski et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Immunology

IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection

Laura J. Pallett et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus

Peng Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Immunology

An essential role for the IL-2 receptor in Treg cell function

Takatoshi Chinen et al.

NATURE IMMUNOLOGY (2016)

Review Immunology

Regulatory T Cells in Hepatitis B and C Virus Infections

Min Kyung Jung et al.

IMMUNE NETWORK (2016)

Editorial Material Immunology

Overview of the special issue on HBV immunity

Antonio Bertoletti et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

Review Immunology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

William M. Schneider et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Article Gastroenterology & Hepatology

Reduction of HBV replication prolongs the early immunological response to IFNα therapy

Anthony T. Tan et al.

JOURNAL OF HEPATOLOGY (2014)

Article Multidisciplinary Sciences

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

Elizabeth B. Wilson et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

Dorothea Busse et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Immunology

A function for interleukin 2 in Foxp3-expressing regulatory T cells

JD Fontenot et al.

NATURE IMMUNOLOGY (2005)

Article Medicine, General & Internal

Peginterferon alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B

GKK Lau et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Biochemistry & Molecular Biology

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

JN Blattman et al.

NATURE MEDICINE (2003)

Article Medicine, General & Internal

Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection.

MW Fried et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)