期刊
DRUG DELIVERY
卷 28, 期 1, 页码 2348-2360出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2021.1995078
关键词
Butenafine; nanoparticles; irritation study; optimization; antifungal activity
资金
- King Saud University, Riyadh, Saudi Arabia [RSP-2021/146]
The study aimed to prepare and optimize butenafine-loaded PLGA nanoparticles (BT-NPs). The optimized BT-NPopG formulation showed slow drug release, enhanced permeation, minimal irritation, and higher antifungal activity compared to marketed and pure BT, making it an ideal delivery system for topical fungal infections.
The present research work is designed to prepare and optimize butenafine (BT) loaded poly lactic co glycolic acid (PLGA) nanoparticles (BT-NPs). BT-NPs were prepared by emulsification probe sonication method using PLGA (A), PVA (B) as polymer and stabilizer, respectively. The optimum composition of BT-NPs was selected based on the point prediction method given by the Box Behnken design software. The optimized composition of BT-NPop showed a particle size of 267.21 +/- 3.54 nm with an entrapment efficiency of 72.43 +/- 3.11%. The optimum composition of BT-NPop was further converted into gel formulation using chitosan as a natural polymer. The prepared topical gel formulation (BT-NPopG) was further evaluated for gel characterization, drug release, permeation study, irritation, and antifungal studies. The prepared BT-NPopG formulation showed optimum pH, viscosity, spreadability, and drug content. The release and permeation study results revealed slow BT release (42.76 +/- 2.87%) with significantly enhanced permeation across the egg membrane. The irritation study data showed negligible irritation with a cumulative score of 0.33. The antifungal study results conclude higher activity than marketed as well as pure BT. The overall conclusion of the results revealed BT-NPopG as an ideal delivery system to treat topical fungal infection.
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