Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ

Mulberry leaves are rich in 1-deoxynojirimycin (DNJ) and 2-O-alpha-d-galactopyranosyl-deoxynojirimycin (GAL-DNJ). Compared to DNJ, the bioactive potency of GAL-DNJ is low. We proposed that the conversion of GAL-DNJ into DNJ may improve its bioavailability. We evaluated this hypothesis and constructed a novel enzymatic-based method to induce the hydrolysis of GAL-DNJ to DNJ in order to improve the therapeutic potency of mulberry leaves.

Automated summary

Studies have shown that converting GAL-DNJ to DNJ may enhance the therapeutic potency of mulberry leaves, leading to the proposal of an enzymatic-based method. This novel approach aims to improve the bioavailability and effectiveness of mulberry leaves through the hydrolysis of GAL-DNJ to DNJ.