Plasma Exchange-Based Non-bioartificial Liver Support System Improves the Short-Term Outcomes of Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure: A Multicenter Prospective Cohort Study

Article Gastroenterology & Hepatology

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF

Jiang Li et al.

Summary: This study suggests that immune-metabolism disorder triggered by HBV exacerbation may be a potential mechanism of HBV-ACLF, providing a novel diagnostic and treatment target to reduce HBV-ACLF-related mortality.

GUT (2022)

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Review Gastroenterology & Hepatology

Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

Gabriel Mezzano et al.

Summary: The study revealed high global prevalence and mortality rates of ACLF, with regional variations possibly explained by triggers/aetiology of CLD or grade.

GUT (2022)

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Review Gastroenterology & Hepatology

The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

Vicente Arroyo et al.

Summary: Systemic inflammation may be a key feature of acute decompensation of cirrhosis, affecting organ system function through various mechanisms and working synergistically with traditional pathways to contribute to the development of AD. It can exacerbate splanchnic vasodilation by overactivating the endogenous vasoconstrictor systems, leading to hypoperfusion in certain vascular beds such as the renal circulation. Additionally, systemic inflammation may cause immune-mediated tissue damage and induce significant metabolic changes.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure

Jonel Trebicka et al.

Summary: The gut microbiome plays an important role in the development of liver diseases, potentially driving decompensation and progression to ACLF by inducing systemic inflammation. Further investigation into the role of the gut microbiome in the pathogenesis of decompensated cirrhosis and ACLF is warranted.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Medicine, General & Internal

Cohort profile: a multicentre prospective validation cohort of the Chinese Acute-on-Chronic Liver Failure (CATCH-LIFE) study

Liang Qiao et al.

Summary: The CATCH-LIFE study aims to fill the gaps in research on acute-on-chronic liver failure, collecting a wealth of clinical information and samples through two phases of investigation and validation cohorts. Future plans involve comparing new ACLF diagnostic criteria derived from the validation cohort data with existing ones, as well as conducting proteomic and metabolic omics analyses to advance specific therapy development.

BMJ OPEN (2021)

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Review Critical Care Medicine

Uncertainty in the impact of liver support systems in acute-on-chronic liver failure: a systematic review and network meta-analysis

Klementina Ocskay et al.

Summary: In acute-on-chronic liver failure (ACLF), plasma exchange (PE) appears to be the best liver support therapy currently available, significantly improving patient survival rates and reducing the need for organ transplants according to the results of the network meta-analysis. Additional randomized trials are needed to confirm these findings and potentially introduce new devices.

ANNALS OF INTENSIVE CARE (2021)

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Article Gastroenterology & Hepatology

Therapeutic plasma-exchange improves systemic inflammation and survival in acute-on-chronic liver failure: A propensity-score matched study from AARC

Rakhi Maiwall et al.

Summary: Plasma-exchange has been shown to improve systemic inflammation and lower the development of multiorgan failure in patients with acute liver failure. It provides significant survival benefit over Fractional Plasma Separation and Adsorption and could be a preferred modality of liver support for ACLF patients. Plasma-exchange cleared inflammatory cytokines, damage-associated molecular patterns, and endotoxin in all patients, and responders showed improved immune function and cytokine levels compared to non-responders.

LIVER INTERNATIONAL (2021)

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Article Gastroenterology & Hepatology

Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

Richard Moreau et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Surgery

OPTN/SRTR 2018 Annual Data Report: Deceased Organ Donation

A. K. Israni et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Review Gastroenterology & Hepatology

Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review

Eunice Xiang-Xuan Tan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Plasma perfusion combined with plasma exchange in chronic hepatitis B-related acute-on-chronic liver failure patients

Zhongyuan Yang et al.

HEPATOLOGY INTERNATIONAL (2020)

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Article Hematology

Therapeutic plasma exchange in acute on chronic liver failure

Klaus Stahl et al.

JOURNAL OF CLINICAL APHERESIS (2020)

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Article Gastroenterology & Hepatology

The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Jonel Trebicka et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Medicine, Research & Experimental

Comparison of plasma exchange, double plasma molecular adsorption system, and their combination in treating acute-on-chronic liver failure

Xiju Guo et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Review Cell Biology

Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure

Mireia Casulleras et al.

CELLS (2020)

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Article Hematology

Therapeutic effect of double plasma molecular adsorption system and sequential half-dose plasma exchange in patients with HBV-related acute-on-chronic liver failure

Jia Yao et al.

JOURNAL OF CLINICAL APHERESIS (2019)

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Editorial Material Gastroenterology & Hepatology

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update

Shiv Kumar Sarin et al.

HEPATOLOGY INTERNATIONAL (2019)

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Article Hematology

Therapeutic plasma exchange in acute liver failure

Klaus Stahl et al.

JOURNAL OF CLINICAL APHERESIS (2019)

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Article Hematology

Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT

Krystin Krauel et al.

BLOOD (2019)

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Article Gastroenterology & Hepatology

Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure

Tianzhou Wu et al.

GUT (2018)

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Article Public, Environmental & Occupational Health

Acute-on-Chronic Liver Failure in China: Rationale for Developing a Patient Registry and Baseline Characteristics

Wen-yi Gu et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2018)

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Article Hematology

Prognostic factors and treatment effect of standard-volume plasma exchange for acute and acute-on-chronic liver failure: A single-center retrospective study

Ya-Lien Cheng et al.

TRANSFUSION AND APHERESIS SCIENCE (2018)

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Review Oncology

Current advances in the elimination of hepatitis B in China by 2030

Shuye Zhang et al.

FRONTIERS OF MEDICINE (2017)

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Review Gastroenterology & Hepatology

Bacterial translocation markers in liver cirrhosis

Alexandra Alexopoulou et al.

ANNALS OF GASTROENTEROLOGY (2017)

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Article Critical Care Medicine

Molecular Adsorbent Recirculating System Can Reduce Short-Term Mortality Among Patients With Acute-on-Chronic Liver Failure-A Retrospective Analysis

Hans U. Gerth et al.

CRITICAL CARE MEDICINE (2017)

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Article Gastroenterology & Hepatology

The effect of plasma exchange on entecavir-treated chronic hepatitis B patients with hepatic de-compensation and acute-on-chronic liver failure

Wan Yue-Meng et al.

HEPATOLOGY INTERNATIONAL (2016)

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Review Hematology

How I treat patients with a history of heparin-induced thrombocytopenia

Theodore E. Warkentin et al.

BLOOD (2016)

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Article Gastroenterology & Hepatology

Plasma exchange-centered artificial liver support system of hepatitis B virus-related acute-on-chronic liver failure: a nationwide prospective multicenter study in China

Jia-Jia Chen et al.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2016)

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Article Gastroenterology & Hepatology

High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial

Fin Stolze Larsen et al.

JOURNAL OF HEPATOLOGY (2016)

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Review Gastroenterology & Hepatology

Acute-on-chronic liver failure: terminology, mechanisms and management

Shiv K. Sarin et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

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Article Virology

Changing etiologies and outcome of liver failure in Southwest China

Gui-Juan Xie et al.

VIROLOGY JOURNAL (2016)

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Article Multidisciplinary Sciences

Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B

Hai Li et al.

SCIENTIFIC REPORTS (2016)

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Article Surgery

OPTN/SRTR 2013 Annual Data Report: liver

W. R. Kim et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2015)

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Article Gastroenterology & Hepatology

Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults

Yu Shi et al.

HEPATOLOGY (2015)

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Editorial Material Gastroenterology & Hepatology

Toward an Improved Definition of Acute-on-Chronic Liver Failure

Rajiv Jalan et al.

GASTROENTEROLOGY (2014)

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Article Gastroenterology & Hepatology

The Global Burden of Liver Disease: The Major Impact of China

Fu-Sheng Wang et al.

HEPATOLOGY (2014)

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Article Engineering, Biomedical

A single-center experience of non-bioartificial liver support systems among Chinese patients with liver failure

Qi Xia et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2014)

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Review Gastroenterology & Hepatology

Pathological bacterial translocation in liver cirrhosis

Reiner Wiest et al.

JOURNAL OF HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

Richard Moreau et al.

GASTROENTEROLOGY (2013)

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Article Medicine, Research & Experimental

Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure

Tianyan Chen et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2012)

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Article Gastroenterology & Hepatology

Influential factors of prognosis in lamivudine treatment for patients with acute-on-chronic hepatitis B liver failure

Li-Jie Sun et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2010)

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Article Gastroenterology & Hepatology

Prediction value of model for end-stage liver disease scoring system on prognosis in patients with acute-on-chronic hepatitis B liver failure after plasma exchange and lamivudine treatment

Jian-Wu Yu et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2008)

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Article Gastroenterology & Hepatology

Model for End-Stage Liver Disease (MELD) and allocation of donor livers

R Wiesner et al.

GASTROENTEROLOGY (2003)

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Article Gastroenterology & Hepatology

A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts

M Malinchoc et al.

HEPATOLOGY (2000)

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Article Hematology

Effect of plasma exchange on serum tissue inhibitor of metalloproteinase 1 and cytokine concentrations in patients with fulminant hepatitis

T Nakamura et al.

BLOOD PURIFICATION (2000)

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Plasma Exchange-Based Non-bioartificial Liver Support System Improves the Short-Term Outcomes of Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure: A Multicenter Prospective Cohort Study

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